DSIP 10 mg

Molecular mechanism of action: DSIP does not act as a sedative; it acts as a modulator of several regulatory systems via complementary pathways.
(1) Slow-wave sleep: modulation of thalamocortical activity associated with delta waves, without central nervous system depression.
(2) Regulation of the hypothalamic-pituitary-adrenal (HPA) axis: attenuation of CRH and ACTH release, accompanied by a decrease in circulating corticosterone in stress models.
(3) Antinociception: potentiation of the endogenous opioid system (metenkephalin), with documented analgesic effects in animal models.
(4) Neuroendocrine modulation: influence on GH and LH secretion, interaction with somatostatin.
(5) Antioxidant action: reduction of oxidative stress and stabilization of cell membranes.

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• Sleep architecture and delta activity (slow waves)
• Regulation of the HPA axis and cortisol (models of chronic stress)
• Antinociception and pain perception threshold
• Physiological recovery and nocturnal secretion of growth hormone (GH)
• Chronobiology and resynchronization of circadian rhythms
• Withdrawal protocols (opioids, alcohol) and withdrawal symptoms
• Neuroprotection and resistance to oxidative stress

Analytical data

• Sequence: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu (WAGGDASGE)
• Chemical formula: C35H48N10O15
• Molecular weight: 848.8 Da
• HPLC Purity: $\ge 99\%$ (certified by Janoshik; certificate of analysis available per batch)
• Form: White, sterile, freeze-dried powder
• Solubility: Bacteriostatic water, sterile water, physiological saline solution
• Storage of freeze-dried powder: Up to 24 months at -20°C
• Storage after reconstitution: 4 weeks at +4°C, protected from light

10 mg format — For whom?

The 10 mg format corresponds to the reference packaging for DSIP in the scientific literature. Reconstitution with 1 ml of bacteriostatic water yields a concentration of 10 mg/ml, while reconstitution with 2 ml gives a concentration of 2.5 mg/ml, thus facilitating precise sample fractionation. This format is suitable for short- to medium-duration protocols, without exposing the lyophilized powder to unnecessary handling cycles.

Reconstruction and conservation

Reconstitute with sterile or bacteriostatic water (recommended concentration: 2.5 to 5 mg/mL). Inject the solvent along the side of the vial without vigorous shaking: DSIP is sensitive to mechanical stress. The reconstituted solution is stable for 4 weeks at +4°C, protected from light. Unreconstituted lyophilized powder can be stored for up to 24 months at -20°C. Avoid repeated freeze-thaw cycles and prolonged contact with air after reconstitution.